Projects

• The role of miRNAs in breast cancer development

  This project is looking at the role of disregulated miRNAs in the development of breast cancer.

  

• Toxoplasma: parasitic subversion of host function

  Infection by Toxoplasma are a cause of morbidity and mortality worldwide. This project, in collaboration with Jim Ajioka in Pathology and Arnab Pain at KAUST, focuses on the genomics and proteomics of Toxoplasma infection, and the changes it brings about in the host, with a focus on potential therapy targets.

  

• Genomics of coral reefs

  We are sequencing the dinoflagellate (Symbiodinium) and the host Stylophora genomes, in order to study symbiotic interactions of coral reefs, as well as host-parasite dynamics.

  

• Data integration

  We have created and continue to develop the data warehouse system InterMine, as well as a number of databases that use the system.

  

• Bdelloid rotifer genomics

  Bdelloid rotifers are microscopic animals that reproduce asexually and are able to survive dessication. As such, their genomes contain unique adaptations, some of which are the focus of this project.

  A project in collaboration with Alan Tunnacliffe.

  

• Synthetic biology

  We are developing a data warehouse for the exploitation of standard genetic parts from a range of organisms. We also co-organise the Cambridge iGEM competition team and a Cambridge synthetic biology forum.

  

For more details see Projects.